Thermo Fisher Scientific Phospho-IRAK1 (Thr209) Polyclonal Antibody
Phospho-IRAK1 (Thr209) 항체로, 인간·마우스·랫트 시료에 반응. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Rabbit Polyclonal IgG로 Protein A 정제. -20°C 보관, 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from mouse IRAK1 around the phosphorylation site of Thr209 [QG(p-T)CN] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. IRAK1 can also phosphorylate TIRAP, promoting its ubiquitination and degradation, and phosphorylate IRF7 to induce activation and nuclear translocation, resulting in type I IFN gene transcription and antiviral response.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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