Thermo Fisher Scientific CMKLR1 Polyclonal Antibody
CMKLR1 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC, Flow, ELISA 등에 사용 가능. Human, Mouse, Pig, Rat 반응성. Protein A 정제, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from mouse CMKLR1 (amino acids 151–250) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin (RARRES2) and the omega-3 fatty acid-derived molecule resolvin E1. Interaction with RARRES2 activates intracellular signaling molecules such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK, and PI3K, leading to various effects including reduction of immune responses, enhancement of adipogenesis, and angiogenesis. Resolvin E1 reduces cytokine production in macrophages by down-regulating MAPK1/3 (ERK1/2) and NF-kappa-B activation. CMKLR1 positively regulates adipogenesis and adipocyte metabolism and acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR, SIVSM62A) as well as a primary HIV-1 strain (92UG024-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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