Thermo Fisher Scientific PFKFB1/PFKFB4 Polyclonal Antibody
Rabbit polyclonal antibody recognizing endogenous PFKFB1/4. Validated for WB and ICC/IF. Supplied as unconjugated liquid form (1 mg/mL). Suitable for research on glycolysis and glucose homeostasis regulation.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PFKFB1 (Accession P16118), corresponding to amino acid residues I329–I379 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815883 |
Product Specific Information
Antibody detects endogenous levels of total PFKFB1/4.
Target Information
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes.
The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains.
Fructose-2,6-biphosphate acts as an activator of glycolysis and an inhibitor of gluconeogenesis.
Regulation of fructose-2,6-biphosphate levels by this enzyme is thought to control glucose homeostasis.
Multiple alternatively spliced transcript variants have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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