Thermo Fisher Scientific SIK2 Polyclonal Antibody
Thermo Fisher Scientific의 SIK2 Polyclonal Antibody는 인간 SIK2 단백질을 인식하는 토끼 유래 IgG 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 and 650 of Human salt-inducible kinase 2 (SIK2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
SNF1LK2 (QIK) is a serine/threonine kinase and a salt-inducible kinase belonging to the AMP-activated protein kinase family.
It negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator TORC.
SIK2 is involved in signaling cascades regulating insulin-induced genes PGC-1α and UCP-1 in brown adipocytes, with implications in obesity and insulin resistance.
Additionally, SIK2 is a key regulator of neuronal survival after ischemia, suppressing CREB-mediated gene expression following oxygen-glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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