Thermo Fisher Scientific Pannexin 2 Polyclonal Antibody

Thermo Fisher Scientific Pannexin 2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Gap junctions are channel-forming structures that enable direct metabolic and electrical communication between adjacent cells in mammalian tissues. They are absent only in adult skeletal muscle cells and certain circulating blood cells. Each gap junction consists of two hemichannels, one in each neighboring cell, composed of six subunits.

In mice and humans, at least 20 connexin and 3 pannexin genes encode gap junction proteins. Connexins are found only in chordates, while pannexins are present in both chordate and invertebrate genomes. Pannexins, previously known as innexins, are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini.

Both human and mouse genomes contain three pannexin-encoded genes. Pannexin 2 (Px2, PANX2) is a brain-specific gene abundantly expressed in the central nervous system, similar to pannexin 1. In neuronal populations such as hippocampus, olfactory bulb, cortex, and cerebellum, pannexin 1 and pannexin 2 are co-expressed, whereas in white matter only pannexin 1-positive cells are found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.