Thermo Fisher Scientific CDH11 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains. Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain.

Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups. Type I cadherins include cadherins E (epithelial), N (neural), P (placental), and R (retinal). Type II cadherins include human cadherin-5, -6, -8, -11, and -12, defined by their lack of a HAV cell adhesion recognition sequence specific to type I cadherins.

Cadherin-11 (OB-Cadherin) is a marker of the loosely connected and migratory mesenchymal cellular elements. Strong expression has been noted in brain, spinal cord, bone marrow, and bone cells, and is regulated in human endometrial glandular epithelial and stromal cells. Its expression in osteoblastic cell lines and upregulation during differentiation suggest a role in bone development and maintenance.

A variant Cadherin-11 gene encodes a truncated protein with an unusual cytoplasmic domain generated by alternative splicing. Cadherin-11 mRNA and protein are expressed in invasive breast cancer cell lines but not in non-invasive lines, suggesting its potential as a marker for aggressive tumor subsets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.