Thermo Fisher Scientific ICAD Polyclonal Antibody
인간 ICAD 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:20–1:200 |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1:200–1:2,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human DNA fragmentation factor subunit alpha protein (1–331 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.67 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C or −80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092353 |
Target Information
ICAD (Inhibitor of Caspase-3-Activated DNase) is a substrate controlling nuclear apoptosis. It exists in two isoforms:
- ICAD-L/DFF45 (45 kDa) – functional isoform
- ICAD-S/DFF35 (35 kDa) – non-functional isoform
Both isoforms bind and inhibit CAD, but only ICAD-L is functional. Upon caspase-3 activation, ICAD is cleaved at residues 117 and 224, releasing CAD to execute apoptotic DNA fragmentation. In non-apoptotic cells, CAD remains complexed with ICAD. ICAD also acts as a CAD-specific folding chaperone.
Recent studies suggest ICAD may be a therapeutic target for restoring normal apoptotic pathways in colon and brain cancers. Two alternatively spliced transcript variants encode distinct isoforms of ICAD.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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