Thermo Fisher Scientific Metadherin Polyclonal Antibody
Metadherin 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC, ELISA, IP 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피 정제. 인체 반응성, 액상 형태로 안정적 보관 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1:200–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Protein LYRIC protein (1–260AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.95 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3091544 |
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a novel protein that localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is recruited during the maturation of the tight junction complex rather than serving as a structural component. Metadherin is overexpressed in breast cancer tissue and xenografts, while lower levels are found in normal breast tissue. It binds to lung vasculature, a common site of breast cancer metastasis, via a C-terminal extracellular segment. Blocking this domain with antibodies or inhibiting Metadherin using siRNA has been reported to reduce breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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