Thermo Fisher Scientific RGS22 Polyclonal Antibody
Thermo Fisher Scientific의 RGS22 Polyclonal Antibody는 인간 및 랫트 시료에 반응하며 Western blot과 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제된 비접합 항체로, Jurkat cell lysate를 양성 대조군으로 사용할 수 있습니다. RGS22는 G단백질 신호 조절에 관여하며 암 전이 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid synthetic peptide near the amino terminus of human RGS22 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551778 |
Product Specific Information
- Suggested positive control: Jurkat cell lysate
- PA5-34426 can be used with blocking peptide PEP-1468.
Target Information
Regulator of G-protein signaling (RGS) proteins contain a conserved 120 amino acid RGS domain that acts as a GTPase-activating protein to reduce the signal transmitted by receptor-activated G-alpha subunits.
RGS22 is a recently identified member of this family that localizes to the testis and interacts with guanine nucleotide-binding proteins GNA11, GNA12, and GNA13.
It may play a role in spermiogenesis and is expressed in several epithelial-origin cancer cell lines, associated with metastasis. Overexpression reduces cell migration and invasiveness, suggesting RGS22 as a potential prognostic biomarker for metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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