Thermo Fisher Scientific Alivin 1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Alivin 1,uniProtId:Q80ZD9-1,ncbiNodeId:10090,antigenRange:449-464|450-464,antigenLength:519,antigenImageFileName:PA1-4357_Alivin_1_Q80ZD9-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4357_Alivin_1_Q80ZD9-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2226576

Product Specific Information

PA1-4357 detects the alivin 1 protein in mouse and rat samples.

PA1-4357 has been successfully used in Western blot procedures. By Western blot this antibody detects bands of ~63 and 66 kDa representing alivin 1 in mouse brain lysate.

The PA1-4357 immunogen is a synthetic peptide correspondiing to residues T(449) G D A S A D D R K A G K R V V(464) of mouse and rat alivin 1. There is 81% sequence identity to human.

Target Information

A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimers disease type 5 and Parkinsons disease 8 on human chromosome 12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.