Thermo Fisher Scientific CIDEC Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues L(10) L Y P K S L S R H V S V R T S(25) of human CIDE-3. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CIDEC,uniProtId:Q96AQ7-1,ncbiNodeId:9606,antigenRange:10-25|11-25,antigenLength:238,antigenImageFileName:PA1-4316_CIDEC_Q96AQ7-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4316_CIDEC_Q96AQ7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2079998

Product Specific Information

PA1-4316 detects the human CIDE-3 protein in human samples. Expected to recognize mouse samples due to 93% sequence homology.

PA1-4316 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~27 kDa protein representing human CIDE-3 in HepG2 cell lysate.

The PA1-4316 immunogen is a synthetic peptide corresponding to residues L(10) L Y P K S L S R H V S V R T S(25) of human CIDE-3. This antibody shows cross-reactivity to FSP27, which is the mouse homolog of CIDE-3, with a sequence identity of 93%.

Maintain at 4ºC for 3 months or at -20ºC for longer periods. Avoid repeated freeze-thaw cycles.

Target Information

DNA fragmentation is one of the critical steps in apoptosis, which is induced by DNA fragmentation factor (DFF). DFF is composed of two subunits, a 40 kDa caspase-activated nuclease (DFF40) and a 45 kDa inhibitor (DFF45). Recently a novel family of cell-death-inducing DFF45-like effectors (CIDEs) has been identified. Human CIDE-3 is a novel member of CIDEs. There are 2 transcripts, CIDE-3 and CIDE-3alpha, were present in HepG2 and A375 cells. Consistent with its chromosome localization at 3p25, a region associated with high frequency loss of heterozygosity in many tumours, CIDE-3 may play an important role in prevention of tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.