Thermo Fisher Scientific Calcineurin B Polyclonal Antibody
Calcineurin B 단백질 인식용 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합하며 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:50,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 1–154 of Human Calcineurin B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.76 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547413 |
Product Specific Information
- Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, mouse fetal brain, rat brain, MEF
- Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (97%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Calcineurin is a Ser/Thr, calcium and calmodulin-dependent protein phosphatase essential in T cell activation. It consists of two subunits:
- Calcineurin A (CnA): 60 kDa catalytic subunit
- Calcineurin B (CnB): 19 kDa regulatory subunit containing four EF-hand calcium binding sites
Calcineurin-mediated dephosphorylation of NF-AT is critical for its activation, nuclear translocation, and gene expression in T-cells. Immunosuppressive drugs such as cyclosporin A and FK506 inhibit NF-AT activation by binding to calcineurin subunits through immunophilin complexes, blocking substrate access to the catalytic domain.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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