Thermo Fisher Scientific CD123 Monoclonal Antibody (5B11), FITC, eBioscience
마우스 CD123 (IL-3 수용체 α사슬)을 인식하는 단클론 항체로, FITC 형광 표지되어 있습니다. Flow cytometry 분석에 최적화되어 있으며, 1 µg/test 권장. 488 nm 청색 레이저에서 520 nm 방출. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD123 Monoclonal Antibody (5B11), FITC, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1 µg/test
Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B11 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465192 |
Additional Formats
Product Specific Information
The 5B11 monoclonal antibody reacts with mouse CD123, the alpha chain of the IL-3 receptor. This 60–70 kDa transmembrane protein binds IL-3 with low affinity alone, and with high affinity when associated with CD131 (common beta chain) or AIC2A (IL-3β). CD123 requires the beta chain for signal transduction.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse bone marrow cell suspension; ≤1 µg/test recommended.
A test is defined as the amount of antibody that stains a cell sample in 100 µL volume (typically 10^5–10^8 cells/test).
Careful titration is recommended for optimal assay performance.
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-3Ra (Interleukin-3 receptor subunit alpha) is part of the type I cytokine receptor family. It forms a heterodimer with the common beta (CDw131) subunit, transmitting IL-3 signaling. IL-3Ra and IL-3Rb heterodimerization is induced by IL-3 and is essential for receptor activation.
IL-3Ra is reported to be overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells, making it a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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