Thermo Fisher Scientific PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target) Recombinant Rabbit Monoclonal Antibody (PDL1/8591R)
PD-L1(Programmed Death Ligand 1) 표적을 인식하는 재조합 토끼 단클론 항체. 인체 시료에 반응하며 IHC(P) 실험에 적합. Protein A/G 정제 및 PBS 버퍼 내 0.05% BSA 함유. 암 면역치료 연구용으로 T세포 반응 조절 연구에 활용 가능.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDL1/8591R |
| Immunogen | Recombinant fragment (around aa190–290) of human CD274 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human placenta, spleen, or tonsil tissue
- Cellular Location: Cell surface and cytoplasm
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a member of the B7 family. Its receptor, PD-1, negatively regulates T-cell receptor (TCR) signaling. Upon binding to PD-1, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be upregulated by IFN-gamma stimulation. PD-L1 plays a critical role in tumor immune evasion mechanisms.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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