Thermo Fisher Scientific PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target) Recombinant Rabbit Monoclonal Antibody (PDL1/8222R)
PD-L1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, 암 면역치료 연구에 적합합니다. Western blot 및 면역조직화학(IHC) 실험에 사용 가능하며, CHO 세포에서 발현된 고순도 항체입니다. 단백질 A/G로 정제되었으며, 보존제가 없는 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDL1/8222R |
| Immunogen | Recombinant fragment (around aa190–290) of human CD274 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a member of the B7 family. Its receptor, programmed death receptor 1 (PD-1), negatively regulates T-cell receptor (TCR) signaling. Upon binding to PD-1, PD-L1 can decrease TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in various human and murine cancers and can be upregulated by IFN-gamma stimulation, suggesting its role in tumor immune evasion.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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