Thermo Fisher Scientific PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target) Recombinant Rabbit Monoclonal Antibody (PDL1/8809R)
PD-L1 (CD274) 표적의 재조합 토끼 단클론 항체로 암 면역치료 연구용 적합. 인체 반응성, IHC(Paraffin) 검증 완료. 단백질 A/G 정제, 액상 형태, 4°C 보관. 세포 표면 및 세포질 PD-L1 검출에 사용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDL1/8809R |
| Immunogen | Recombinant fragment (around aa190–290) of human CD274 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human placenta, spleen, or tonsil tissue
- Cellular Location: Cell Surface, Cytoplasm
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a member of the B7 family. Its receptor, PD-1, negatively regulates T-cell receptor (TCR) signaling. PD-L1 binding to PD-1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be up-regulated upon IFN-gamma stimulation, suggesting a role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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