Thermo Fisher Scientific GRIK1 Polyclonal Antibody, Biotin
GluR5 단백질을 인식하는 토끼 폴리클로날 항체로, Biotin으로 표지됨. Western blot, ELISA, IP에 적합. Mouse와 Rat 시료 반응성. Affinity chromatography로 정제되어 높은 특이성과 재현성 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid region on GluR5 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1 (glutamate receptor 5) belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.
Grik1 is expressed in GABAergic interneurons of the hippocampus and is thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological, and neurodegenerative diseases.
Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which can alter ion flow properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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