Thermo Fisher Scientific GRIK1 Polyclonal Antibody, FITC
FITC로 표지된 GRIK1 폴리클로날 항체로, Western blot, ELISA, IP에 적합합니다. 마우스 및 랫트 반응성이 있으며, Affinity chromatography로 정제되었습니다. 신경전달 관련 GluR5 타깃 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid region on GluR5 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.
Grik1 (glutamate receptor 5) belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.
Grik1 is expressed in GABAergic interneurons of the hippocampus and is thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2.
Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological, and neurodegenerative diseases.
Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which can alter ion flow properties.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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