Thermo Fisher Scientific CD1d Monoclonal Antibody (51.1), APC, eBioscience
인간 CD1d 단백질을 인식하는 단클론 항체로, APC로 결합되어 유세포 분석(Flow Cytometry)에 최적화됨. 51.1 클론은 CD1d-NKT 상호작용 차단 기능을 가짐. 4°C 보관, 동결 금지. 연구용으로만 사용 가능.
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- 판매단위
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 51.1 |
| Conjugate | APC |
| Excitation/Emission Max | 651/660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11219079 |
Available Formats
Product Specific Information
The monoclonal antibody 51.1 reacts with human CD1d, a member of the CD1 family related to non-polymorphic MHC Class I-like molecules. CD1d is a conserved transmembrane receptor that can associate with beta-microglobulin or exist independently, suggesting multiple mechanisms for glycolipid antigen presentation to NKT cells. Expression occurs on peripheral B cells, resting monocytes, cortical thymocytes, and intestinal epithelial cells. Elevated expression is observed in HCV-infected livers.
The 51.1 antibody has functional blocking activity, inhibiting interactions between CD1d-transfected cells and NKT cells.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and validated for flow cytometry using normal human peripheral blood cells
- Recommended Use: 5 µL (0.125 µg) per 100 µL test volume
- Excitation: 633–647 nm
- Emission: 660 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD1d forms a heavy chain associated with beta-2 microglobulin on cortical thymocytes. Independent expression also occurs on intestinal epithelial cells. It is the sole group 2 member of the CD1 family of MHC-like glycoproteins. The CD1d gene encodes a transmembrane glycoprotein structurally related to MHC proteins, forming heterodimers with beta-2 microglobulin. CD1 proteins mediate lipid and glycolipid antigen presentation to T cells. The human genome contains five CD1 genes on chromosome 1, differing in localization and lipid ligand specificity. CD1d localizes to late endosomes and lysosomes via a tyrosine-based motif. Diseases associated with CD1D include Mycobacterium malmoense infection and autoimmune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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