Thermo Fisher Scientific KIR3DL2 Polyclonal Antibody
Thermo Fisher Scientific의 KIR3DL2 Polyclonal Antibody는 인간, 생쥐, 랫드 시료에서 KIR3DL2 단백질 검출에 적합합니다. Western blot과 ELISA에 사용 가능하며, 고순도의 rabbit IgG 폴리클로날 항체입니다. 세포막 단백질 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 361–455 of human KIR3DL2 (NP_006728.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.65 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804315 |
Product Specific Information
- Positive Samples: HL-60, LO2, MCF7, Mouse spleen, Mouse liver, Rat spleen
- Cellular Location: Cell membrane, Single-pass type I membrane protein
- Immunogen Sequence:
YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF
Target Information
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous, found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
The gene content of the KIR gene cluster varies among haplotypes, although several framework genes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) are found in all haplotypes.
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain.
KIR proteins with long cytoplasmic domains transduce inhibitory signals via immune tyrosine-based inhibitory motifs (ITIM), while those with short cytoplasmic domains lack ITIM and associate with TYRO protein tyrosine kinase binding protein to transduce activating signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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