Thermo Fisher Scientific PTCH Polyclonal Antibody
PTCH 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC, ELISA 등 다양한 응용 가능. 인간, 생쥐, 랫트 반응성. 고순도 Affinity Chromatography 정제, 안정적 PBS/glycerol 저장. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1214–1312 of human PTCH1 (NP_0002552) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.79 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804210 |
Product Specific Information
- Immunogen sequence: THSGSDSSDS EYSSQTTVSG LSEELRHYEA QQGAGGPAHQ VIVEATENPV FAHSTVVHPE SRHHPPSNPR QQPHLDSGSL PPGRQGQQPR RDPPREGLW
- Positive Samples: 293T, Mouse liver
- Cellular Location: Membrane, Multi-pass membrane protein
Target Information
This gene encodes a member of the patched gene family. The encoded protein acts as the receptor for sonic hedgehog, a secreted molecule involved in embryonic development and tumorigenesis, as well as desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations are associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, and holoprosencephaly.
Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-87508_PTCH_Q13635-1_Rabbit.svg, PA5-87508_PTCH_Q13635-1_Rabbit_PDP.jpeg)
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