Thermo Fisher Scientific NR4A2 Monoclonal Antibody (2A3)
NR4A2 단백질을 표적으로 하는 마우스 단클론 항체로, 인간 시료에 반응합니다. Western blot과 ELISA에 적용 가능하며, 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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- H00004929-M13
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Thermo Fisher Scientific NR4A2 Monoclonal Antibody (2A3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A3 |
| Immunogen | NR4A2 (NP_006177, 147–250 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GSLHNFHQNY VATTHMIEQR KTPVSRLSLF SFKQSPPGTP VSSCQMRFDG PLHVPMNPEP AGSHHVVDGQ TFAVPNPIRK PASMGFPGLQ IGHASQLLDT QVPS*
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans.
NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene have been linked to disorders associated with dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression.
Misregulation of NR4A2 may also be associated with rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, and additional splice variants may exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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