Thermo Fisher Scientific NR4A2 Monoclonal Antibody (3E10)
NR4A2(Nurr1) 단백질을 인식하는 Mouse monoclonal antibody(3E10)로 Western blot 및 ELISA에 적합. 인간 시료 반응성. Affinity chromatography로 정제된 액상 제품이며, PBS(pH 7.4) buffer에 보존제 미첨가. -20°C 보관, 동결·해동 반복 피할 것.
- 카탈로그번호
- H00004929-M06
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E10 |
| Immunogen | NR4A2 (AAH66890, 71 a.a. ~170 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GFQVQHSPMW DDPGSLHNFH QNYVATTHMI EQRKTPVSRL SLFSFKQSPP GTPVSSCQMR FDGPLHVPMN PEPAGSHHVV DGQTFAVPNP IRKPASMGFP
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is a transcription factor encoded by the NR4A2 gene in humans.
Nurr1 plays a key role in maintaining the dopaminergic system of the brain. Mutations in this gene are associated with dopaminergic dysfunction-related disorders such as Parkinson’s disease, schizophrenia, and manic depression. Misregulation may also be linked to rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, with potential additional splice variants yet to be fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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