Thermo Fisher Scientific DISC1 Polyclonal Antibody
DISC1 단백질을 인식하는 토끼 폴리클로날 항체로, 마우스 시료에 반응합니다. Western blot 및 IHC에 사용 가능하며, 합성 펩타이드 항원을 기반으로 제작되었습니다. 신경세포 구조 및 이동 관련 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 802–852 of mouse DISC1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: DISC1.
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system. It is involved in neuronal functions dependent on cytoskeletal regulation, including neuronal migration, neurite architecture, and intracellular transport.
Regions of the brain expressing DISC1 include:
- Hippocampus
- Lateral septum
- Amygdala
- Cerebral cortex
- Cerebellum
- Paraventricular hypothalamus
Loss of DISC1 function results in differences in structural organization. The DISC1 gene locus is associated with schizophrenia due to chromosomal translocations. DISC1 encodes a large protein with a globular N-terminal domain and a helical C-terminal domain, both capable of protein interactions.
DISC1 interacts with:
- Centrosome/cytoskeletal proteins: MIPT3, MAP1A, NUDEL
- Membrane receptor-localizing proteins: alpha-actinin 2, beta 4-spectrin
- Signal transduction proteins: ATF-4, ATF-5
DISC1 is thought to play roles in intracellular transport, neurite architecture, and neuronal migration, processes implicated in schizophrenia pathology. Decreased DISC1 expression in neurons accelerates neuronal integration and causes abnormal morphological development, suggesting its role in dendritic development and synapse formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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