Thermo Fisher Scientific DISC1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: DISC1.

Target Information

DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system. It is involved in neuronal functions dependent on cytoskeletal regulation, including neuronal migration, neurite architecture, and intracellular transport.

Regions of the brain expressing DISC1 include:

• Hippocampus
• Lateral septum
• Amygdala
• Cerebral cortex
• Cerebellum
• Paraventricular hypothalamus

Loss of DISC1 function results in differences in structural organization. The DISC1 gene locus is associated with schizophrenia due to chromosomal translocations. DISC1 encodes a large protein with a globular N-terminal domain and a helical C-terminal domain, both capable of protein interactions.

DISC1 interacts with:

• Centrosome/cytoskeletal proteins: MIPT3, MAP1A, NUDEL
• Membrane receptor-localizing proteins: alpha-actinin 2, beta 4-spectrin
• Signal transduction proteins: ATF-4, ATF-5

DISC1 is thought to play roles in intracellular transport, neurite architecture, and neuronal migration, processes implicated in schizophrenia pathology. Decreased DISC1 expression in neurons accelerates neuronal integration and causes abnormal morphological development, suggesting its role in dendritic development and synapse formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.