Thermo Fisher Scientific DNAL1 Polyclonal Antibody
DNAL1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 IHC에 적합하며, 사람 단백질에 반응. 합성 펩타이드(aa 2-40)로부터 제작. 동결건조 형태로 제공되며, 4°C 또는 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 2–40 of human DNAL1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of MQ water.
- Centrifuge to remove any insoluble material.
- Specificity: DNAL1.
Target Information
DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterogeneous disorder characterized by chronic infections of the upper and lower airways, which can lead to permanent lung damage, randomization of left/right body symmetry, and reduced fertility.
DNAL1 is expressed in tissues with motile cilia or flagella and interacts with DNAH5, a protein whose mutation can cause PCD. It may serve a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia.
Additionally, DNAL1 has been identified as an HIV dependency factor (HDF), suggesting potential as a drug target in HIV treatment.
At least two isoforms of DNAL1 are known.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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