Thermo Fisher Scientific DISC1 Polyclonal Antibody
DISC1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC에 사용 가능. 마우스 DISC1의 600–650 aa 영역 합성 펩타이드로 면역화. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. 신경세포 발달 및 정신분열증 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 600–650 of mouse DISC1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: DISC1.
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system. It is involved in neuronal functions dependent on proper cytoskeletal regulation, including neuronal migration, neurite architecture, and intracellular transport.
DISC1 is expressed in the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus. Loss of DISC1 function leads to differences in structural organization. The DISC1 gene locus is associated with schizophrenia due to chromosomal translocations.
DISC1 encodes a large protein with a globular N-terminal domain and a helical C-terminal domain, both capable of protein–protein interactions. It interacts with:
- Centrosome and cytoskeletal proteins: MIPT3, MAP1A, NUDEL
- Membrane receptor localization proteins: alpha-actinin 2, beta 4-spectrin
- Signal transduction proteins: ATF-4, ATF-5
DISC1 is implicated in intracellular transport, neurite architecture, and neuronal migration, processes that may contribute to schizophrenia pathology. Decreased DISC1 expression accelerates neuronal integration and causes abnormal dendritic development, suggesting a role in dendritic and synaptic formation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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