Thermo Fisher Scientific DISC1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: DISC1.

Target Information

DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system. It is involved in neuronal functions dependent on proper cytoskeletal regulation, including neuronal migration, neurite architecture, and intracellular transport.

DISC1 is expressed in the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus. Loss of DISC1 function leads to differences in structural organization. The DISC1 gene locus is associated with schizophrenia due to chromosomal translocations.

DISC1 encodes a large protein with a globular N-terminal domain and a helical C-terminal domain, both capable of protein–protein interactions. It interacts with:

• Centrosome and cytoskeletal proteins: MIPT3, MAP1A, NUDEL
• Membrane receptor localization proteins: alpha-actinin 2, beta 4-spectrin
• Signal transduction proteins: ATF-4, ATF-5

DISC1 is implicated in intracellular transport, neurite architecture, and neuronal migration, processes that may contribute to schizophrenia pathology. Decreased DISC1 expression accelerates neuronal integration and causes abnormal dendritic development, suggesting a role in dendritic and synaptic formation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.