Thermo Fisher Scientific CRYGC Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:20,000

Product Specifications

Product Specific Information

• Recommended positive controls: A431, mouse eye
• Predicted reactivity: Mouse (83%), Rat (85%), Dog (87%), Rhesus Monkey (96%), Chimpanzee (99%), Bovine (85%), Guinea pig (86%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Crystallins are separated into two classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class forms the major proteins of vertebrate eye lens, maintaining transparency and refractive index. Lens fiber cells lose their nuclei during development, so crystallins are produced and retained throughout life, making them extremely stable.

Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins form a superfamily. Seven structural regions exist: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are monomeric, symmetrical proteins lacking connecting peptides and terminal extensions, and are differentially regulated after early development. Mutations or aging-related changes in gamma-crystallins are associated with cataract formation.

⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.