Thermo Fisher Scientific TSPO Polyclonal Antibody
TSPO 단백항체로 인간 시료에 반응하며 Western blot과 IHC(Paraffin)에 적합합니다. Rabbit Polyclonal 형식으로 고순도 친화 크로마토그래피 정제 제품입니다. 스테로이드 합성 관련 연구 및 미토콘드리아 단백질 분석에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human PBR aa 1–183 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854634 |
Product Specific Information
Positive Control: A431, PC-3M, human colon cancer tissue, human kidney tissue, mouse colon tissue, mouse brain tissue.
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, mediating the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation.
PBR is composed of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier.
It is genetically conserved from bacteria to humans and widely expressed in peripheral organs; in the brain, expression is mainly in glial cells.
Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits Leydig cell steroidogenesis by affecting PBR mRNA stability, thus reducing PBR expression, cholesterol transport into mitochondria, and steroid formation.
A cytoplasmic protein, PRAX-1 (Peripheral Benzodiazepine Receptor-Associated Protein 1), specifically interacts with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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