Thermo Fisher Scientific PSMA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Control: Human small intestine tissue lysate, HepG2, PC-3M.

Target Information

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues such as prostate, central and peripheral nervous system, and kidney.
A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and hyperhomocysteinemia. Expression in the brain may be involved in pathological conditions associated with glutamate excitotoxicity. In the prostate, the protein is up-regulated in cancerous cells and serves as a diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.