Thermo Fisher Scientific VEGF Receptor 3 Polyclonal Antibody
인간 VEGF Receptor 3를 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. 면역세포염색(ICC/IF)에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human VEGF Receptor 3. Recombinant protein control fragment (Product #RP-108373) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856645 |
Product Specific Information
Immunogen sequence:
LEWAWPGAQE APATGDKDSE DTGVVRDCEG TDARPYCKVL LLHEVHANDT GSYVCYYKYI KARIEGTTAA SSYVFVRDFE QPFINKPDTL LVNRKDAMWV PCLVSIPGLN VTLRSQSSVL WPDGQEVVWD DRRGMLVSTP LLH
Target Information
Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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