Thermo Fisher Scientific MEKK1 Polyclonal Antibody
Human MEKK1 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 40% glycerol buffer에 보존됩니다. MAPK 신호전달 연구용으로 사용됩니다.
- 카탈로그번호
- PA5111232
- 판매단위
- pk
카탈로그
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MEKK1. Recombinant protein control fragment: Product #RP-106119 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2856642 |
Product Specific Information
Immunogen sequence:
SSSKCDDSFG CSSNSSNAVI PSDETVFTPV EEKCRLDVNT ELNSSIEDLL EASMPSSDTT VTFKSEVAVL SPEKAENDDT YKDDVNHNQK CKEKMEAEEE EALAIAMAMS ASQDALPIVP QLQVENGEDI IIIQQ
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells.
MEKK1 can phosphorylate and activate MAPKK1 and MAPKK2 (MEK1/MEK2), leading to phosphorylation of MAP kinases.
It is also a highly efficient activator of the JNK cascade.
The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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