Thermo Fisher Scientific Phospho-Androgen Receptor (Ser83) Polyclonal Antibody
인산화된 Androgen Receptor(Ser83)을 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에 적합하며, Human, Mouse, Rat에 반응. 고순도 정제, PBS/glycerol buffer로 안정적 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-Androgen Receptor (Ser83) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC(P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AR (Accession P10275), corresponding to amino acid residues around phosphorylated Ser83 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817327 |
Product Specific Information
This antibody detects endogenous levels of Androgen Receptor only when phosphorylated at Ser83.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. This receptor (~90 kDa) contains three major functional domains:
- N-terminal domain
- DNA-binding domain
- Androgen-binding domain
AR acts as a ligand-activated transcription factor binding active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
The AR signaling pathway is crucial for the development and function of male reproductive organs (prostate, epididymis) and also affects nonreproductive tissues (muscle, hair follicles, brain). AR is a phosphoprotein involved in MAP kinase regulation. Alterations in AR signaling are associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene can cause complete androgen insensitivity (CAIS).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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