Thermo Fisher Scientific Phospho-BIM (Ser59) Polyclonal Antibody
인간, 생쥐, 랫트에서 Ser59 인산화된 BIM 단백질을 특이적으로 검출하는 폴리클로날 항체. Western blot에 1:1,000~1:3,000 희석으로 사용 가능. 액상 형태, 1 mg/mL 농도, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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- PA5105927
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Thermo Fisher Scientific Phospho-BIM (Ser59) Polyclonal Antibody
Applications
- Western Blot (WB): 1:1,000–1:3,000
Species Reactivity
Human, Mouse, Rat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2L11 (Accession O43521), corresponding to amino acid residues around phosphorylated Ser59 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817326 |
Product Specific Information
This antibody detects endogenous levels of BIM only when phosphorylated at Ser59.
Target Information
BIM belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities. The encoded protein contains a Bcl-2 homology domain 3 (BH3) and interacts with BCL2, BCL2L1/BCL-X(L), and MCL1, functioning as an apoptotic activator. Expression of this gene can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting roles in neuronal and lymphocyte apoptosis. Mouse transgenic studies indicate that this gene acts as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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