Thermo Fisher Scientific Varicella zoster Virus (strain Dumas) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total KR2_VZVD.

Target Information

Varicella Zoster Virus (VZV), a member of the human herpesvirus family, causes two distinct clinical manifestations: childhood chickenpox (Varicella) and shingles (zoster).
Varicella is the outcome of the primary infection with VZV, whereas zoster results from VZV reactivation from latently infected sensory ganglia, occurring predominantly in aging and immunosuppressed individuals.

Glycoprotein E (gE), a 623 amino acid type I integral membrane protein, is expressed on plasma membranes and in the cytoplasm of VZV-infected cells, where it is presumed to be present in intracellular vesicle or organelle membranes.
VZV gE complexes with gI in the rough endoplasmic reticulum, forming gE–gI heterodimers in infected cells. gE is also a predominant component of the virion envelope.

The functions of gE, encoded by ORF68, are essential for VZV replication. In contrast, gE genes can be deleted from herpes simplex virus and pseudorabies virus, though infectivity is significantly reduced.
Since the VZV genome does not encode a homologue of gD, VZV gE may perform functions usually segregated between gD and gE, or the gE–gI complex, in other alphaherpesviruses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.