Thermo Fisher Scientific PAPPA2 Polyclonal Antibody
PAPPA2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합하며 인간, 생쥐, 랫트 시료에 반응. 액상 형태로 1 mg/mL 농도, PBS+50% glycerol 버퍼에 보관. 연구용으로 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PAPPA2 (Accession Q9BXP8), corresponding to amino acid residues I1352–D1402 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900355 |
Product Specific Information
Antibody detects endogenous levels of total PAPP A2.
Target Information
PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in an IGF-independent fashion. The cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Elevated levels of PLAC3 have been observed in hypertensive disorders of pregnancy, including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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