Thermo Fisher Scientific PHIP Polyclonal Antibody
PHIP 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. Human과 Mouse 시료 반응성. 항원 친화 크로마토그래피로 정제되어 순도 95% 이상. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human PHIP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720894 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein containing eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (cytosol and nucleus) and primary beta cells (nucleus), functioning as a transcriptional activator. PHIP interacts with members of the insulin receptor substrate (IRS) family, which mediate insulin receptor signaling and are critical for beta cell proliferation and survival. PHIP associates with the PH domain of IRS-1, linking IRS-1 to insulin receptors and playing a vital role in insulin signaling regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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