Thermo Fisher Scientific IRAK-M Polyclonal Antibody
Human IRAK-M 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제됨. 고순도(>95%) 제품으로 면역 신호전달 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 500–540 of Human IRAK-M |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803277 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
IRAK3 (Interleukin-1 receptor-associated kinase 3, also known as IRAK-M) is a serine/threonine kinase and a member of the IRAK protein family, which are essential components of the Toll/IL-R immune signal transduction pathways.
IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. It mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis.
Mutations in IRAK3 are associated with susceptibility to asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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