Thermo Fisher Scientific Human ZNF536 Synthetic Peptide
인간 ZNF536 단백질의 아미노 말단 16개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-20854의 차단 펩타이드로 사용 가능하며, 신경계 발달 관련 연구에 적합합니다. 고순도 정제되어 PBS(pH 7.2, 0.1% BSA) 용액 형태로 제공됩니다.
- 카탈로그번호
- PEP0968
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human ZNF536 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human ZNF536.
PEP-0968 can be used as a blocking peptide with polyclonal antibody PA5-20854.
Target Information
ZNF536 is a zinc-finger protein expressed primarily in the developing nervous system, including the cerebral cortex, hippocampus, and hypothalamus.
It possesses ten zinc fingers and interacts with CtBP1, a corepressor for gene transcription.
ZNF536 is closely related to transcriptional repressor ZNF219.
Overexpression of ZNF536 in embryonic stem cells reduces mRNA levels of neuronal marker genes (Pax6, MAP2, beta-tubulin III) after retinoic acid (RA)-induced differentiation.
Conversely, depletion of ZNF536 via RNAi increases these mRNA levels, indicating its role in inhibiting neuronal cell differentiation.
Overexpression of RA receptor α rescues the inhibitory role of ZNF536, suggesting that ZNF536 may inhibit RA response element-mediated transcriptional activity.
주의사항
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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