Thermo Fisher Scientific Human TMEM38A Synthetic Peptide
인간 TMEM38A의 C-말단 근처 17개 아미노산 서열로 구성된 합성 펩타이드입니다. PA5-20858 항체의 블로킹 펩타이드로 사용 가능하며, 액상 형태로 제공됩니다. 200 µg/mL 농도, PBS(pH 7.2) 버퍼에 0.1% BSA 및 0.02% sodium azide 포함. 연구용으로만 사용.
- 카탈로그번호
- PEP0972
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human TMEM38A Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human TMEM38A.
PEP-0972 can be used as a blocking peptide with polyclonal antibody PA5-20858.
Target Information
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes.
TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues.
Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca²⁺ handling, weakened Ca²⁺ release, and reduced K⁺ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca²⁺ release from intracellular stores.
Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca²⁺ release in muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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