Thermo Fisher Scientific Human TMEM38A Synthetic Peptide

Thermo Fisher Scientific Human TMEM38A Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the carboxy terminus of human TMEM38A.
PEP-0972 can be used as a blocking peptide with polyclonal antibody PA5-20858.

Target Information

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes.
TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues.
Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca²⁺ handling, weakened Ca²⁺ release, and reduced K⁺ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca²⁺ release from intracellular stores.
Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca²⁺ release in muscle cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.