Thermo Fisher Scientific ABHD3 Monoclonal Antibody (A5D4)

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Target Information

The α/β hydrolase superfamily comprises diverse members involved in important biochemical processes and various diseases. Despite unrelated sequences and substrate variety, they share a canonical α/β hydrolase fold with an eight-stranded parallel α/β structure and a catalytic triad composed of histidine, acid, and nucleophile. Members are often drug targets for conditions such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders.

The α/β hydrolase domain containing (ABHD) gene subfamily includes 15 mostly uncharacterized members, many of which use a serine nucleophile forming the G-X-S-X-G nucleophile elbow.

• ABHD1: Metabolizes smoking xenobiotics
• ABHD2: Participates in atherosclerosis development
• ABHD3: 409 amino acid single-pass type II membrane protein
• ABHD4: Involved in alternative synthesis of N-acyl ethanolamine (NAE)
• ABHD5: Mutations contribute to Chanarin-Dorfman syndrome
• ABHD6: May play a role in nervous system metabolism and signaling

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.