Thermo Fisher Scientific GLI2 Monoclonal Antibody (OTI1G2), TrueMAB
Human GLI2 단백질(aa 729-1123)을 인식하는 Mouse IgG1 단클론 항체. Western blot에 최적화되어 있으며, Lyophilized 형태로 제공. 연구용으로만 사용 가능하며, 재구성 시 1 mg/mL 농도로 조정 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 729–1123 of human GLI2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Gli-2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. These transcription factors bind DNA through conserved H-C zinc finger motifs and mediate Sonic hedgehog (Shh) signaling. Gli family proteins are implicated as oncogenes in embryonal carcinoma cells.
The GLI2 protein localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It also plays roles in embryogenesis and is associated with several phenotypes, including:
- Greig cephalopolysyndactyly syndrome
- Pallister-Hall syndrome
- Preaxial polydactyly type IV
- Postaxial polydactyly types A1 and B
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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