Thermo Fisher Scientific HDAC8 (near N-terminus) Polyclonal Antibody
HDAC8 단백질의 N-말단 근처를 인식하는 Rabbit Polyclonal Antibody로, Western Blot, ELISA, Immunoprecipitation에 적합합니다. 인간 HDAC8에 반응하며, 고순도 Affinity chromatography로 정제된 액상 제품입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 600-401-J72
- 판매단위
- pk
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Thermo Fisher Scientific HDAC8 (near N-terminus) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-HDAC8 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide near the N-terminus of human HDAC8 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 30% glycerol, 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
A BLAST analysis suggests cross-reactivity with rat, mouse, human, and bovine based on 100% sequence homology. Cross-reactivity with HDAC8 from other sources has not been determined.
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling, a critical component of transcriptional regulation, is influenced by the acetylation and deacetylation of nucleosomal histones. Histone acetylation increases DNA accessibility to transcription factors, while deacetylation is associated with transcriptional silencing.
Several mammalian proteins act as nuclear histone acetylases, including GCN5, PCAF, p300/CBP, HAT1, and TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase with distinct tissue distribution and nuclear localization, playing roles in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 600-401-J72_HDAC8_Q9BY41-1_Rabbit.svg, 600-401-J72_HDAC8_Q9BY41-1_Rabbit_PDP.jpeg)
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