Thermo Fisher Scientific CD223 (LAG-3) Monoclonal Antibody (3DS223H), Alexa Fluor 647, eBioscience
인간 CD223(LAG-3)을 인식하는 3DS223H 단클론 항체로, Alexa Fluor 647 형광 표지. Flow cytometry 및 IHC(P) 적용 가능. T세포 활성 조절 및 Tr1 세포 연구에 유용. 고순도 친화 크로마토그래피 정제, 4°C 암소 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50
Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
- Publications: 6 available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3DS223H |
| Immunogen | hCD223-FC PFA 4% |
| Conjugate | Alexa Fluor™ 647 |
| Excitation / Emission Max | 650 / 671 nm |
| Form | Liquid |
| Concentration | 5 µL / Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2744739 |
Additional Available Formats
- Alexa Fluor 660
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 395, 563, 661, 737, 805
- Brilliant Violet 421, 480, 605, 650, 711, 786
- eFluor 450, 506
- FITC
- NovaFluor Blue 510, Blue 660-120S, Red 700, Yellow 590, Yellow 610, Yellow 700, Yellow 730
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436, 600, 645, 702, 780
- Custom conjugation available upon request
Product Specific Information
This 3DS223H monoclonal antibody recognizes human CD223 (Lymphocyte Activation Gene 3, LAG-3).
LAG-3 is a 70-kDa surface glycoprotein of the Ig superfamily, homologous to CD4, binding MHC class II with higher affinity.
It plays a role in negative regulation of T cell activation and homeostatic proliferation.
Surface expression is observed on activated T cells (including regulatory T cells) and NK cells, with CD8+ T cells expressing higher levels than CD4+ T cells.
Coexpression of LAG-3 and CD49b identifies human and mouse Type 1 regulatory T cells (Tr1 cells).
This antibody recognizes a formaldehyde-fixed epitope and is validated for flow cytometry analysis of stimulated human peripheral blood cells.
Recommended usage: 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Excitation: 633–647 nm; Emission: 668 nm; Laser: Red Laser.
Target Information
LAG-3 is a 70-kDa surface glycoprotein of the Ig superfamily, homologous to CD4.
It binds MHC class II with higher affinity than CD4 and negatively regulates T cell activation and proliferation.
Expressed on activated T cells and NK cells; CD8+ T cells show higher expression.
Coexpression with CD49b identifies Type 1 regulatory T cells (Tr1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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