Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Rabbit polyclonal antibody against human Tyrosine Hydroxylase. Validated for WB, ICC/IF, and IP applications. High specificity for catecholamine synthesis enzyme. Suitable for research on neurological and cardiovascular diseases. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,500–1:50,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminus of Human Tyrosine Hydroxylase (UniProt ID: P07101-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2902901 |
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the catalytic domain to activate the enzyme.
In humans, four TH mRNA splice variants (hTH1–hTH4) exist, differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-DOPA and plays a critical role in adrenergic neuron physiology.
Alterations in TH function are associated with neurological and cardiovascular diseases including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and others.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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