Thermo Fisher Scientific Phospho-Btk (Tyr551) Recombinant Rabbit Monoclonal Antibody (BtkY551-G12), FITC
FITC로 표지된 재조합 토끼 단클론 항체로, 인산화된 Btk(Tyr551)을 특이적으로 인식합니다. 유세포 분석(Flow Cytometry)에 적합하며, Human 시료에 반응합니다. Protein A/G로 정제되었으며, PBS와 BSA buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA537122
- 판매단위
- pk
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BtkY551-G12 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr551 of human phospho Btk |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897056 |
Available Formats
- Unconjugated (MA5-37120)
- APC (MA5-37123)
- Biotin (MA5-37213)
- PE (MA5-37121)
- Custom conjugation available upon request
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
BTK interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which are key molecules in innate and adaptive immunity. It also interacts with proteins involved in TLR4 signal transduction, including MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting its role in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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