Thermo Fisher Scientific TYMS Monoclonal Antibody (OTI1B2), TrueMAB
Human TYMS 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 Western blot 및 IHC(P) 검증 완료. DNA 합성 관련 효소 Thymidylate Synthase 연구에 적합. 동결건조 형태로 제공되며, 고순도 친화 크로마토그래피 정제 제품.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B2 |
| Immunogen | Full length human recombinant protein of human TYMS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), essential for DNA biosynthesis.
TS is a key target for fluoropyrimidine antineoplastic drugs such as 5-FU and fluorodeoxyuridine. These compounds are converted to FdUMP, which inactivates TS by forming a ternary covalent complex with 5,10-methylenetetrahydrofolate.
TS expression correlates with response to 5-FU in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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