Thermo Fisher Scientific TOP1MT Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TOP1MT. Recombinant protein control fragment (Product #RP-100991). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TOP1MT,uniProtId:Q969P6-1,ncbiNodeId:9606,antigenRange:40-143,antigenLength:601,antigenImageFileName:PA5-54444_TOP1MT_Q969P6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54444_TOP1MT_Q969P6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648819

Product Specific Information

Immunogen sequence: ARWEKEKHED GVKWRQLEHK GPYFAPPYEP LPDGVRFFYE GRPVRLSVAA EEVATFYGRM LDHEYTTKEV FRKNFFNDWR KEMAVEEREV IKSLDKCDFT EIHR

Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 73%.

Target Information

This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.