Thermo Fisher Scientific MFN1 Polyclonal Antibody
MFN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에서 반응합니다. Western blot 및 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 2–8°C에서 보관 가능합니다.
- 카탈로그번호
- PA538042
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 3 publications |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 17 amino acid peptide near the amino terminus of human MFN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C (up to 3 months); -20°C (long-term storage) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2554646 |
Product Specific Information
- Recommended positive control: A431 cell lysate
- MFN1 antibody is not expected to cross-react with MFN2.
Target Information
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes.
MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion, essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in Bax but not its mitochondrial translocation, indicating MFN1’s role in regulating Bax activation on the outer mitochondrial membrane.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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