Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI16C1), TrueMAB
Thermo Fisher Scientific의 ACY1 단클론 항체(OTI16C1)는 인간 단백질을 인식하는 Mouse IgG1 항체로, Western blot, IHC(P), Flow cytometry에 적합합니다. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 완충액에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI16C1 |
| Immunogen | Full length human recombinant protein of human ACY1 produced in HEK293 cell. Target family: Aminoacylase (UniProt ID: Q03154-1, NCBI Taxonomy ID: 9606, amino acid range: 1–408). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), where its expression is often reduced or undetectable.
The human aminoacylase-1 sequence is highly homologous to the porcine counterpart and represents the first member of a zinc-binding enzyme family.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder associated with CNS defects and increased urinary N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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