Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI1B12), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is thought to function in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), where expression is often reduced or undetectable. The human aminoacylase-1 sequence is highly homologous to the porcine enzyme and represents the first member of a family of zinc-binding enzymes.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder with CNS defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing produces multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.