Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI1B12), TrueMAB
ACY1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, Flow Cytometry에 적합. Human, Mouse, Rat, Dog 반응성. Affinity chromatography로 정제된 액상 항체로, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B12 |
| Immunogen | Full length human recombinant protein of human ACY1 produced in HEK293 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.28 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is thought to function in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), where expression is often reduced or undetectable. The human aminoacylase-1 sequence is highly homologous to the porcine enzyme and represents the first member of a family of zinc-binding enzymes.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder with CNS defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing produces multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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